Reaktion #1363668

Reaktionsgleichung

1-benzyl-3-(SR)-hydroxymethyl-4-(SR)-phenylpyrrolidine

→

title compound

Ausbeute 100.5%

3-(SR)-Hydroxymethyl-4-(SR)-phenylpyrrolidine

Ausbeute 100.5%

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was filtered
2. 2
   Einengenthe filtrate was concentrated in vacuo

Vorschrift

A mixture of 302 mg (1.1 mmol) of 1-benzyl-3-(SR)-hydroxymethyl-4-(SR)-phenylpyrrolidine (from Example 1, Step B) and 154 mg of 20% Pd(OH)2/C was hydrogenated at 40 psi on a Paar apparatus for 1 h. The catalyst was filtered and the filtrate was concentrated in vacuo to afford 196 mg (98%) of the title compound as an oil. 1H NMR (500 MHz, CDCl3): δ2.53-2.57 (m, 2H), 3.06-3.60 (6H), 7.24-7.35 (5H). Mass Spectrum (NH3-CI): m/z 178 (M+1).

Quelle