Reaktion #1363058

Reaktionsgleichung

2-Methyl-4-thiazolecarboxylic acid ethyl ester

N-bromosuccinimide

benzoyl peroxide

→

product

2-Bromomethyl-4-thiazolecarboxylic acid, ethyl ester

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 20 hours
2. 2
   TemperaturAfter cooling
3. 3
   Waschenthe reaction mixture was washed with saturated aqueous sodium bicarbonate
4. 4
   Trocknendried (MgSO4)
5. 5
   Sonstigeevaporated under reduced pressure
6. 6
   SonstigePurification
7. 7
   Wascheneluting with 40% ethyl acetate in isohexane

Vorschrift

2-Methyl-4-thiazolecarboxylic acid ethyl ester (1 g) (Liebigs Ann. Chem. 1981, 623), N-bromosuccinimide (1.04 g) and a catalytic amount of benzoyl peroxide in chloroform (25 ml) was heated at reflux for 20 hours. After cooling, the reaction mixture was washed with saturated aqueous sodium bicarbonate, dried (MgSO4) and evaporated under reduced pressure. Purification was by chromatography eluting with 40% ethyl acetate in isohexane to give the product as an oil. Yield 0.5 g.

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