Reaktion #1359527

Reaktionsgleichung

methyl 4-(bromomethyl)benzoate

5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol

→

title compound

Ausbeute 76.0%

methyl 4-(((5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-yl)oxy)methyl)benzoate

Ausbeute 76.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained in Reference Example 18

Vorschrift

Using methyl 4-(bromomethyl)benzoate and 5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Reference Example 18, the title compound was synthesized in the same manner as in Example 94. Oily material. Yield 76%. 1H-NMR (CDCl3) δ: 1.36 (3H, s), 1.59 (3H, s), 2.09 (3H, s), 2.26 (6H, s), 3.10–3.30 (8H, m), 3.79 (3H, s), 3.91 (3H, s), 4.57 (2H, s), 4.69 (1H, s), 6.86 (2H, d, J=9.2 Hz), 6.97 (2H, d, J=9.2 Hz), 7.39 (2H, d, J=8.0 Hz), 7.99 (2H, d, J=8.0 Hz).

Quelle