Reaktion #1356509

Reaktionsgleichung

hydroxy[bis(4-methylphenyl)]acetic acid

N-{3-[1-(3-aminopropyl)-4-piperidinyl]-4-methylphenyl}-2-methylpropanamide

→

N-(3-{1-[3-({hydroxy[bis(4-methylphenyl)]acetyl}amino)propyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamide

Reaktionsbedingungen

Vorschrift

Example 157 was prepared from hydroxy[bis(4-methylphenyl)]acetic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]-4-methylphenyl}-2-methylpropanamide according to the procedures described in Scheme 12: 1H NMR (400 MHz, CDCl3) δ 8.80–8.59 (s, br, 1 H), 7.91 (s, 1 H), 7.42 (d, 4 H, J=8.4 Hz), 7.15 (s, 1 H), 7.09 (d, 4 H, J=8.0 Hz), 7.04 (d, 1 H, J=8.0 Hz), 6.96–6.78 (br, 1 H), 5.30–5.05 (br, 1 H), 3.55–3.41 (m, 2 H), 3.15–3.00 (m, 2 H), 2.82–2.64 (m, 1 H), 2.59–2.46 (m, 2 H), 2.40–2.27 (m, 1 H), 2.30 (s, 6 H), 2.28 (s, 3 H), 2.17–1.95 (m, 4 H), 1.83–1.56 (m, 4 H), 1.02 (d, 6 H, J=6.8 Hz); ESMS m/e: 556.4 (M+H)+.

Quelle