Reaktion #1352266

ord-3e4377aa165b4d8c96a5b93a5e0c3bba

Reaktionsgleichung

O=C=N[C@@H]1C[C@H]1c1ccccc1
trans-2-phenylcyclopropyl isocyanate
CCOCc1nc2c(N)nc(C)c(C)c2n1CCC1CCNCC1
2-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amine
→
CCOCc1nc2c(N)nc(C)c(C)c2n1CCC1CCN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)CC1
desired compound
CCOCc1nc2c(N)nc(C)c(C)c2n1CCC1CCN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)CC1
4-{2-[4-amino-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl]ethyl}-N-[(1R*,2S*)-2-phenylcyclopropyl]piperidine-1-carboxamide

Edukte

O=C=N[C@@H]1C[C@H]1c1ccccc1
trans-2-phenylcyclopropyl isocyanate
CCOCc1nc2c(N)nc(C)c(C)c2n1CCC1CCNCC1
2-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using the method of Examples 54-65, trans-2-phenylcyclopropyl isocyanate was reacted with 2-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The observed accurate mass was 491.3139.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06545017B1uspto-grants-2003_04