Reaktion #1352262

ord-fe622257009e4fa780a3eae8c32e275d

Reaktionsgleichung

O=C=N[C@@H]1C[C@H]1c1ccccc1
trans-2-phenylcyclopropyl isocyanate
Cc1nc(N)c2ncn(CCCCN)c2c1C
1-(4-aminobutyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine
→
Cc1nc(N)c2ncn(CCCCNC(=O)N[C@@H]3C[C@H]3c3ccccc3)c2c1C
desired compound
Cc1nc(N)c2ncn(CCCCNC(=O)N[C@@H]3C[C@H]3c3ccccc3)c2c1C
N-[4-(4-amino-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)butyl]-N′-[(1R*,2S*)-2-phenylcyclopropyl]urea

Edukte

O=C=N[C@@H]1C[C@H]1c1ccccc1
trans-2-phenylcyclopropyl isocyanate
Cc1nc(N)c2ncn(CCCCN)c2c1C
1-(4-aminobutyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using the method of Examples 16-26, trans-2-phenylcyclopropyl isocyanate was reacted with 1-(4-aminobutyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The observed accurate mass was 393.2425.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06545017B1uspto-grants-2003_04