Reaktion #1352073

Reaktionsgleichung

sodium hydroxide

compound

1-methyl-3,4-dihydroisoquinoline

sodium borohydride

hydrochloric acid

→

titled compound

Ausbeute 93.9%

1-methyl-1,2,3,4-tetrahydroisoquinoline

Ausbeute 93.9%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to below 5° C.
2. 2
   Extraktionextracted with ethyl acetate
3. 3
   TrocknenThe ethyl acetate layer was dried over anhydrous sodium sulfate
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To the suspension of sodium borohydride (5.28 g, 138 mmol) in ethanol, was added the compound (19.8 g, 133.8 mmol) prepared in Step 2 above. The reaction mixture was stirred for 1 hour at room temperature, cooled to below 5° C. acidified with diluted hydrochloric acid, neutralized with sodium hydroxide solution, and extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated in vacuo to give 18.5 g of the titled compound.

Quelle