Reaktion #1350576

Reaktionsgleichung

3-methoxyphenylacetyl chloride

3-(3-aminophenyl)-4-bromo-1-methylpyrazole

triethylamine

→

title compound

Ausbeute 19.0%

N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl]-2-(3-methoxyphenyl)acetamide

Ausbeute 19.0%

Lösungsmittel

dichloromethane

dichloromethane

brine

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe organic layer was washed with more brine
2. 2
   Trocknenthen dried over magnesium sulphate
3. 3
   Einengenconcentrated in vacuo
4. 4
   SonstigeThe crude product was purified by column chromatography (ethyl acetate-toluene, 1:1)

Vorschrift

A solution of 3-methoxyphenylacetyl chloride (0.02 ml, 0.12 mmol) in dichloromethane (0.75 ml) was added dropwise at 0° C. to a solution of 3-(3-aminophenyl)-4-bromo-1-methylpyrazole (30 mg, 0.12 mmol) and triethylamine (0.02 ml, 0.13 mmol) in dichloromethane (0.75 ml). The resulting mixture was stirred at room temperature for 16 h and then poured into brine. The organic layer was washed with more brine then dried over magnesium sulphate and concentrated in vacuo. The crude product was purified by column chromatography (ethyl acetate-toluene, 1:1), giving the title compound (9 mg, 19%). Rf 0.30 (ethyl acetate-toluene, 1:1).

Quelle