Reaktion #1350570

Reaktionsgleichung

4-methoxyphenylchloroformate

3-(3-aminophenyl)-4-bromo-1-methylpyrazole

triethylamine

→

title compound

Ausbeute 59.7%

N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl][4-methoxyphenoxy]carboxamide

Ausbeute 59.7%

Lösungsmittel

CH2Cl2

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated

Vorschrift

To 4-methoxyphenylchloroformate (19 mg, 0.10 mmol) in CH2Cl2 (0.5 mL) was added dropwise a solution of 3-(3-aminophenyl)-4-bromo-1-methylpyrazole (25 mg, 0.10 mmol) and triethylamine (14 μL, 0.10 mmol) in CH2Cl2 (0.5 mL). The mixture was stirred for 16 h and concentrated. Chromatography on flash silica (40% EtOAc/hexane) gave the title compound as a colourless solid (24 mg, 526), m.p. 140.3-141.8° C. (EtOAc/hexane).

Quelle