Reaktion #1349177

Reaktionsgleichung

(4-Methyl-piperazin-1-yl)-(3-nitro-phenyl)-methanone

Ethanol

hydrogen

→

(3-Amino-phenyl)-(4-methyl-piperazin-1-yl)-methanone

Ausbeute 80.9%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONthe solution was carefully added to a Parr vessel
2. 2
   FiltrationThe catalyst was then filtered

Vorschrift

(4-Methyl-piperazin-1-yl)-(3-nitro-phenyl)-methanone (2.46 g, 9.87 mmol) was dissolved in Ethanol (30.0 mL, 514 mmol) and the solution was carefully added to a Parr vessel containing 10% Palladium on Carbon (0.750 g, 56.2 mmol) under nitrogen. The mixture was then placed on a Parr hydrogenation apparatus and was allowed to shake at 55 psi until uptake of hydrogen ceased. The catalyst was then filtered to afford 1.75 g of (3-Amino-phenyl)-(4-methyl-piperazin-1-yl)-methanone without further purification. (M+H)=220.6.

Quelle