Reaktion #1347745

ord-ba8251526933499b8c3e3d437c3e79e5

Reaktionsgleichung

CC(C)Oc1ccc(Oc2ccc(CC[C@@H](N)C(C)C)cc2)cn1
(R)-1-{2-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]ethyl}-2-methylpropylamine
CC(=O)OC(C)=O
acetic anhydride
→
CC(=O)N[C@H](CCc1ccc(Oc2ccc(OC(C)C)nc2)cc1)C(C)C
N—((R)-1-{2-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]ethyl}-2-methylpropyl)-acetamide

Edukte

CC(C)Oc1ccc(Oc2ccc(CC[C@@H](N)C(C)C)cc2)cn1
(R)-1-{2-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]ethyl}-2-methylpropylamine
CC(=O)OC(C)=O
acetic anhydride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

(R)-1-{2-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]ethyl}-2-methylpropylamine (48.7 mg, 0.148 mmol) was reacted with acetic anhydride in analogy to example 2a. Yield: 42 mg (77%), M+H+: 371.3.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08470841B2uspto-grants-2013_06