Reaktion #1347736

ord-0cdc841937e7469194399027380682f1

Reaktionsgleichung

CC(N)CCc1ccc(Oc2ccc(OC(C)C)nc2)cc1
3-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]-1-methylpropylamine
O=C(n1ccnc1)n1ccnc1
1,1′-carbonyldiimidazole
→
CC(CCc1ccc(Oc2ccc(OC(C)C)nc2)cc1)NC(N)=O
{3-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}urea

Edukte

CC(N)CCc1ccc(Oc2ccc(OC(C)C)nc2)cc1
3-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]-1-methylpropylamine
O=C(n1ccnc1)n1ccnc1
1,1′-carbonyldiimidazole

Reagenzien

Keine

Lösungsmittel

O=CO
formic acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

3-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]-1-methylpropylamine (115 mg, 0.38 mmol) was reacted with formic acid and 1,1′-carbonyldiimidazole in analogy to example 44. Yield: 5 mg (4%), M+H+: 344.19.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08470841B2uspto-grants-2013_06