Reaktion #1347515

Reaktionsgleichung

(1-pyridin-2-yl-1H-pyrazol-4-yl)-carbamic acid tert-butyl ester

HCl

sodium hydroxide

→

product

Ausbeute 96.0%

1-Pyridin-2-yl-1H-pyrazol-4-ylamine

Ausbeute 96.0%

Lösungsmittel

dioxane

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with dichloromethane
2. 2
   SonstigeThe combined organic phases were dried
3. 3
   Sonstigethe solvent was evaporated

Vorschrift

A solution of (1-pyridin-2-yl-1H-pyrazol-4-yl)-carbamic acid tert-butyl ester (185 mg, 0.72 mmol) in dioxane (1.85 ml) was treated with 4M HCl in dioxane (1.85 ml) and the resulting suspension was stirred at ambient temperature for 2 hours. The reaction mixture was adjusted to basic pH with sodium hydroxide (20 ml, 0.5M aqueous solution) and extracted with dichloromethane. The combined organic phases were dried and the solvent was evaporated to yield the product as light brown solid (110 mg, 96%) which was used without any further purification. MS: M=161.3 (M+H)+

Quelle