Reaktion #1346737

ord-443e8307a01e4f8ebb1053678d7c5e54

Reaktionsgleichung

O=C1N(CCC2CC2)c2ccccc2C1(O)c1cc2c(cc1O)OCO2
1-(2-cyclopropylethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one
O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2C1(O)c1cc2c(cc1O)OCO2
1-(diphenylmethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one
→
O=C1C(c2cc3c(cc2O)OCO3)c2ccccc2N1C(c1ccccc1)c1ccccc1
title compound
O=C1C(c2cc3c(cc2O)OCO3)c2ccccc2N1C(c1ccccc1)c1ccccc1
1-(diphenylmethyl)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one

Edukte

—
2C
O=C1N(CCC2CC2)c2ccccc2C1(O)c1cc2c(cc1O)OCO2
1-(2-cyclopropylethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one
O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2C1(O)c1cc2c(cc1O)OCO2
1-(diphenylmethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the procedure as described in PREPARATION 2C, and making the variations to replace 1-(2-cyclopropylethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one with 1-(diphenylmethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one, the title compound was obtained (84%) as an off-white solid: MS (ES+) m/z 458.4 (M+23).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08466188B2uspto-grants-2013_06