Reaktion #1343158

Reaktionsgleichung

hydrazine hydrate

6-nitro-4-(phenylamino)quinazoline

→

6-amino-4-(phenylamino)quinazoline

Lösungsmittel

ethanol water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeterminating with a fifth reactive group
2. 2
   Sonstigeprepared
3. 3
   FiltrationThe reaction mixture is filtered
4. 4
   Sonstigeevaporated

Vorschrift

A solution of a 6-nitro-4-(phenylamino)quinazoline substituted by a polyalkylene glycol derivative terminating with a fifth reactive group, prepared as described hereinabove, in ethanol/water is reacted at reflux temperature with hydrazine hydrate and Raney®Nickel (Ra—Ni). The reaction mixture is filtered and evaporated, to give the corresponding 6-amino-4-(phenylamino)quinazoline substituted by a polyalkylene glycol moiety terminating with a reactive group.

Quelle