Reaktion #1340567

Reaktionsgleichung

dibenzo[f,h]quinoxaline

hexane

n-butyllithium

3-bromofluorobenzene

→

2-(3-Fluorophenyl)-dibenzo[f,h]quinoxaline

Ausbeute 23.0%

Lösungsmittel

dichloromethane

Water

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated to room temperature
2. 2
   workup.STIRRINGstirred for 12 hours with the temperature
3. 3
   Temperaturmaintained at room temperature
4. 4
   Extraktionwas extracted
5. 5
   TrocknenThe obtained organic layer was dried with anhydrous magnesium sulfate
6. 6
   SonstigeThe solution obtained by the drying
7. 7
   Filtrationwas filtrated
8. 8
   workup.DISTILLATIONThe solvent of this solution was distilled off
9. 9
   Sonstigeby recrystallization with ethanol
10. 10
    Sonstigewas obtained (a light-orange powder, yield: 23%)
11. 11
    SonstigeSynthesis scheme of Step 1

Vorschrift

First, under a nitrogen atmosphere, 27.5 mL (1.58 mol/L) of a hexane solution of n-butyllithium was dripped into a mixed solution of 6.87 g of 3-bromofluorobenzene and 40 mL of tetrahydrofuran at −78° C. Then, with the temperature maintained at −78° C., the mixture was stirred for 2 hours. To the obtained solution was added 7.54 g of dibenzo[f,h]quinoxaline in five additions at −78° C. The mixture was heated to room temperature,and stirred for 12 hours with the temperature maintained at room temperature. Water was added to this mixture and dichloromethane was used as an extraction solvent, so that an organic layer was extracted. The obtained organic layer was dried with anhydrous magnesium sulfate. The solution obtained by the drying was filtrated. The solvent of this solution was distilled off, and then, by recrystallization with ethanol, the organometallic complex of the present invention, Hdbq-3FP, which was the target substance, was obtained (a light-orange powder, yield: 23%). Synthesis scheme of Step 1 is shown in (a-2) below.

Quelle