Reaktion #1337630

ord-8ea91c19ffd74f7a9b5cbbc019b02944

Reaktionsgleichung

BrCc1ccc(Br)cc1
4-bromobenzyl bromide
COC(=O)c1c(C)nc2ccccc2c1N
methyl 4-amino-2-methylquinoline-3-carboxylate
→
COC(=O)c1c(C)nc2ccccc2c1NCc1ccc(Br)cc1
Methyl 4-(4-bromobenzylamino)-2-methylquinoline-3-carboxylate

Edukte

BrCc1ccc(Br)cc1
4-bromobenzyl bromide
—
4-(4-bromobenzylamino-2-methylquinolin-3-yl)ethanone
—
Intermediate 2c
COC(=O)c1c(C)nc2ccccc2c1N
methyl 4-amino-2-methylquinoline-3-carboxylate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Methyl 4-(4-bromobenzylamino)-2-methylquinoline-3-carboxylate was synthesized by the same method as described for 1-(4-(4-bromobenzylamino-2-methylquinolin-3-yl)ethanone (Example 1, Intermediate 2c), starting from methyl 4-amino-2-methylquinoline-3-carboxylate and 4-bromobenzyl bromide. Melting point: 89° C.; MS(ES+): 385/387.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06339077B1uspto-grants-2002_01