Reaktion #1335460

Reaktionsgleichung

2-methyl-3-nitrophenol

ethyl 2-bromobutanoate

potassium carbonate

→

title compound

Ausbeute 93.5%

ethyl 2-(2-methyl-3-nitrophenoxy)butanoate

Ausbeute 93.5%

Lösungsmittel

dimethylformamide

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONThe mixture was then poured over ice
2. 2
   Extraktionextracted twice with diethyl ether
3. 3
   ExtraktionThe combined organic extract
4. 4
   Waschenwas washed with water
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated in vacuo

Vorschrift

A mixture of 5.0 g (32 mmole) of 2-methyl-3-nitrophenol, 4.8 ml (ca. 32 mmole) of ethyl 2-bromobutanoate, and 4.5 g (32 mmole) of potassium carbonate in 50 ml of dimethylformamide was stirred for 18 hours at room temperature. The mixture was then poured over ice, diluted with water, and extracted twice with diethyl ether. The combined organic extract was washed with water, dried over magnesium sulfate, filtered, and concentrated in vacuo to give 8.0 g of the title compound as an analytically pure solid. Structure assignment was supported by nmr and infrared spectra and by elemental analysis.

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