Reaktion #1334740

Reaktionsgleichung

methyl iodide

cesium carbonate

2-[1-benzoyl-3-(2-bromo-5-fluorophenyl)-3-methylbutyl]furan

Na2SO3

citric acid

sodium periodate

→

product

2-Benzoyl-4-(2-bromo-5-fluorophenyl)-4-methylvaleric acid-methyl ester

Lösungsmittel

acetonitrile

MTBE

water acetonitrile tetrachloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe batch is extracted with ethyl acetate
2. 2
   TrocknenThe combined extracts are dried (Na2SO4)
3. 3
   Einengenconcentrated by evaporation in a vacuum
4. 4
   workup.WAITAfter 5 hours at room temperature
5. 5
   Waschenwashed with 10% sulfuric acid and saturated NaCl
6. 6
   Trocknendried (Na2SO4)
7. 7
   Einengenconcentrated by evaporation in a vacuum

Vorschrift

A suspension of 10.9 g (50.8 mmol) of sodium periodate in 140 ml of water-acetonitrile-tetrachloromethane (4:2:1) is mixed with 45 mg (0.34 mmol) of ruthenium(IV)oxide-hydrate. After 10 minutes, a solution of 2-[1-benzoyl-3-(2-bromo-5-fluorophenyl)-3-methylbutyl]furan in 40 ml of acetonitrile is added to it, it is stirred for another 10 minutes, and the batch is poured into 400 ml of saturated Na2SO3. A pH of 5 is set with 10% citric acid, and the batch is extracted with ethyl acetate. The combined extracts are dried (Na2SO4) and concentrated by evaporation in a vacuum. The residue is taken up in 8 ml of DMF and treated with 0.42 ml (6.8 mmol) of methyl iodide and 2.21 g (6.8 mmol) of cesium carbonate. After 5 hours at room temperature, the batch is diluted with 600 ml of MTBE, washed with 10% sulfuric acid and saturated NaCl, dried (Na2SO4) and concentrated by evaporation in a vacuum. Column chromatography on silica gel with hexane-ethyl acetate yields 0.9 g of product.

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