Reaktion #1334606

Reaktionsgleichung

2,4-difluorobenzaldehyde

ethylene glycol

p-toluene sulfonic acid

→

2-(2,4-difluoro-phenyl)-[1,3]dioxolane

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was heated
2. 2
   Temperaturto reflux during 5 hrs (Dean-Stark trap)
3. 3
   Temperaturit was cooled
4. 4
   workup.ADDITIONpoured onto ice
5. 5
   SonstigeThe organic layer was separated off
6. 6
   Waschenwashed with 10% KHCO3-solution and brine
7. 7
   Trocknendried over MgSO4
8. 8
   Filtrationfiltered
9. 9
   Einengenconcentrated

Vorschrift

A stirred solution of 2,4-difluorobenzaldehyde (15.4 ml) in toluene (200 ml) was treated with ethylene glycol (23.2 ml) and p-toluene sulfonic acid (0.53 g). The reaction mixture was heated to reflux during 5 hrs (Dean-Stark trap), then it was cooled to r.t and poured onto ice. The organic layer was separated off, washed with 10% KHCO3-solution and brine, dried over MgSO4, filtered and concentrated to give 2-(2,4-difluoro-phenyl)-[1,3]dioxolane (26.8 g) as a light yellow oil. MS 186.1 ([M]+)

Quelle