Reaktion #1333264

ord-4837b91275164d1fba31a8683e4cee84

Reaktionsgleichung

CN1C(=O)Cc2ccccc21
1-Methyl-1,3-dihydroindol-2-one
Cc1cc(C(=O)O)[nH]c1C=O
5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid
→
Cc1cc(C(=O)O)[nH]c1C=C1C(=O)N(C)c2ccccc21
title compound
Ausbeute 88.6%
Cc1cc(C(=O)O)[nH]c1C=C1C(=O)N(C)c2ccccc21
4-Methyl-5-(1-methyl-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic acid
Ausbeute 88.6%

Edukte

CN1C(=O)Cc2ccccc21
1-Methyl-1,3-dihydroindol-2-one
Cc1cc(C(=O)O)[nH]c1C=O
5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

1-Methyl-1,3-dihydroindol-2-one (147 mg, 1 mmol) was condensed with 5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid (153 mg) using method D to give 250 mg (86%) of the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07125905B2uspto-grants-2006_10