Reaktion #1333112

ord-d8ab58b69dad4af691ad788bdea2b690

Reaktionsgleichung

O=C=N[C@@H]1C[C@H]1c1ccccc1
trans-2-phenylcyclopropyl isocyanate
Cc1nc(N)c2nc(C)n(CCOCCN)c2c1C
1-[2-(2-aminoethoxy)ethyl]-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine
→
Cc1nc(N)c2nc(C)n(CCOCCNC(=O)N[C@@H]3C[C@H]3c3ccccc3)c2c1C
desired compound
Cc1nc(N)c2nc(C)n(CCOCCNC(=O)N[C@@H]3C[C@H]3c3ccccc3)c2c1C
N-{2-[2-(4-Amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl)ethoxy]ethyl}-N′-[(1R*,2S*)-2-phenylcyclopropyl]urea

Edukte

O=C=N[C@@H]1C[C@H]1c1ccccc1
trans-2-phenylcyclopropyl isocyanate
Cc1nc(N)c2nc(C)n(CCOCCN)c2c1C
1-[2-(2-aminoethoxy)ethyl]-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using the method of Examples 54–68, trans-2-phenylcyclopropyl isocyanate was reacted with 1-[2-(2-aminoethoxy)ethyl]-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The product was purified using Method A. The observed accurate mass was 423.2508.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07125890B2uspto-grants-2006_10