Reaktion #1332464

Reaktionsgleichung

N-(1-acetylcyclohexyl)-4-chlorophenyl-methanesulfonamide

4-chloro-phenylmethanesulfonyl chloride

ethynylcyclohexylamine

triethylamine

→

4-chlorophenyl-N-(1-ethynylcyclohexyl)methane-sulfonamide

Ausbeute 80.0%

Lösungsmittel

ethyl acetate

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water
2. 2
   Trocknendried (Na2SO4)
3. 3
   Sonstigeevaporated
4. 4
   SonstigeRecrystallisation from ethanol

Vorschrift

The preparation of N-(1-acetylcyclohexyl)-4-chlorophenyl-methanesulfonamide, shown below, was performed as described in Pestic. Sci. 1993, 39, 185–192. 4-chloro-phenylmethanesulfonyl chloride (1.37 g, 6 mmol) and ethynylcyclohexylamine (0.73 g, 6 mmol) were stirred in tetrahydrofuran (10 mL) with triethylamine (0.9 mL, 6.6 mmol) for several hours at room temperature. The mixture was diluted with ethyl acetate, washed with water, dried (Na2SO4) and evaporated. Recrystallisation from ethanol yielded 4-chlorophenyl-N-(1-ethynylcyclohexyl)methane-sulfonamide (1.5 g, 80%) as a solid.

Quelle