Reaktion #1332016

Reaktionsgleichung

Ammonia

methyl (2S)-2-[2-oxo-(4S)-4-propyl-1-pyrrolidinyl]butanoate

→

(2S)-2-[2-oxo-(4S)-4-propyl-1-pyrrolidinyl]butanamide

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe temperature of the system was maintained at 0–5° C
2. 2
   workup.ADDITIONabove was then added dropwise
3. 3
   Temperaturmaintaining the reaction mixture at 0–5° C
4. 4
   Sonstigecompletion of reaction
5. 5
   workup.WAITAfter standing overnight at ambient temperature
6. 6
   Einengenthe reaction mixture was concentrated at 40° C. under vacuum
7. 7
   Trocknenfurther dried by azyeotropic distillation with toluene

Vorschrift

Ammonia gas was condensed in 2 ml water at 0–5° C. and the temperature of the system was maintained at 0–5° C. 0.68 g of methyl (2S)-2-[2-oxo-(4S)-4-propyl-1-pyrrolidinyl]butanoate obtained such as described above was then added dropwise, maintaining the reaction mixture at 0–5° C. The system was then stirred for 6 hrs, with TLC indicating completion of reaction. After standing overnight at ambient temperature the reaction mixture was concentrated at 40° C. under vacuum and further dried by azyeotropic distillation with toluene to give 150 mg of crude (2S)-2-[2-oxo-(4S)-4-propyl-1-pyrrolidinyl]butanamide.

Quelle