Reaktion #1330115

Reaktionsgleichung

N-[6-[(N,N-Dimethylamino)methyl]-5,6,7,8-tetrahydro-2-naphthalenyl]-4′-[(trifluoroacetyl)amino][1,1′-biphenyl]-4-carboxamide

methanol

sodium hydroxide

→

titled compound

Ausbeute 99.7%

4′-Amino-N-[6-[(N,N-dimethylamino)methyl]-5,6,7,8-tetrahydro-2-naphthalenyl][1,1′-biphenyl]-4-carboxamide

Ausbeute 99.7%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONThe solvent was distilled out under reduced pressure

Vorschrift

N-[6-[(N,N-Dimethylamino)methyl]-5,6,7,8-tetrahydro-2-naphthalenyl]-4′-[(trifluoroacetyl)amino][1,1′-biphenyl]-4-carboxamide (850 mg, 1.72 mmol) obtained in Example 31 was suspended in a mixed solution of methanol (8 ml) and tetrahydrofuran (4 ml), then 1N sodium hydroxide (3.4 ml) was added, which was stirred at 50° C. for 16 hours. The solvent was distilled out under reduced pressure, and the residue was pulverized using water, to give the titled compound (685 mg) as a white powder.

Quelle