Reaktion #1329977

ord-e4709e3cf2564b47bdea5b61bfb8896b

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCN(NC(=O)Cc2ccccc2)CC1
Phenylacetamidopiperazine hydrochloride
CC(C)(C)OC(=O)N1CCN(NC(=O)Cc2ccccc2)CC1
1-BOC-4-phenylacetamidopiperazine
CCc1cc2c(N3CCN(C(=O)OC(C)(C)C)CC3)nc(C(C)C)nc2s1
2-isopropyl-4-chloro-6-ethylthienopyrimidine
CCc1cc2c(N3CCN(C(=O)OC(C)(C)C)CC3)nc(C(C)C)nc2s1
tert-butyl 4-[6-ethyl-2-(methylethyl)thiopheno[3,2-e]pyrimidin-4-yl]piperazinecarboxylate
→
CCc1cc2c(N3CCN(C(=O)Cc4ccccc4)CC3)nc(C(C)C)nc2s1
1-{4-[6-ethyl-2-(methylethyl)thiopheno[3,2-e]pyrimidin-4-yl]piperazinyl}-2-phenylethan-1-one
Ausbeute 21.0%

Edukte

CC(C)(C)OC(=O)N1CCN(NC(=O)Cc2ccccc2)CC1
Phenylacetamidopiperazine hydrochloride
CC(C)(C)OC(=O)N1CCN(NC(=O)Cc2ccccc2)CC1
1-BOC-4-phenylacetamidopiperazine
CCc1cc2c(N3CCN(C(=O)OC(C)(C)C)CC3)nc(C(C)C)nc2s1
2-isopropyl-4-chloro-6-ethylthienopyrimidine
CCc1cc2c(N3CCN(C(=O)OC(C)(C)C)CC3)nc(C(C)C)nc2s1
tert-butyl 4-[6-ethyl-2-(methylethyl)thiopheno[3,2-e]pyrimidin-4-yl]piperazinecarboxylate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Phenylacetamidopiperazine hydrochloride (Example 141) was reacted 2-isopropyl-4-chloro-6-ethylthienopyrimidine (Example 162) according to Example 87. Yield=21%, ES-MS: (M+H)+ 409.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07115741B2uspto-grants-2006_10