Reaktion #1329976

ord-709d684d8c3e483cb77a3e4e904481d2

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCN(NC(=O)Cc2ccccc2)CC1
Phenylacetamidopiperazine hydrochloride
CC(C)(C)OC(=O)N1CCN(NC(=O)Cc2ccccc2)CC1
1-BOC-4-phenylacetamidopiperazine
CCCc1nc(N2CCN(C(=O)OC(C)(C)C)CC2)c2cc(CC)sc2n1
2-propyl-4-chloro-6-ethylthienopyrimidine
CCCc1nc(N2CCN(C(=O)OC(C)(C)C)CC2)c2cc(CC)sc2n1
tert-butyl 4-(6-ethyl-2-propylthiopheno[3,2-e]pyrimidin-4-yl)piperazinecarboxylate
→
CCCc1nc(N2CCN(C(=O)Cc3ccccc3)CC2)c2cc(CC)sc2n1
1-[4-(6-ethyl-2-propylthiopheno[3,2-e]pyrimidin-4-yl)piperazinyl]-2-phenylethan-1-one
Ausbeute 36.0%

Edukte

CC(C)(C)OC(=O)N1CCN(NC(=O)Cc2ccccc2)CC1
Phenylacetamidopiperazine hydrochloride
CC(C)(C)OC(=O)N1CCN(NC(=O)Cc2ccccc2)CC1
1-BOC-4-phenylacetamidopiperazine
CCCc1nc(N2CCN(C(=O)OC(C)(C)C)CC2)c2cc(CC)sc2n1
2-propyl-4-chloro-6-ethylthienopyrimidine
CCCc1nc(N2CCN(C(=O)OC(C)(C)C)CC2)c2cc(CC)sc2n1
tert-butyl 4-(6-ethyl-2-propylthiopheno[3,2-e]pyrimidin-4-yl)piperazinecarboxylate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Phenylacetamidopiperazine hydrochloride (Example 141) was reacted 2-propyl-4-chloro-6-ethylthienopyrimidine (Example 159) according to Example 87. Yield 36%, ES-MS: (M+H)+ 409.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07115741B2uspto-grants-2006_10