Reaktion #1329975

ord-4c1430bfd51b4ad28fda2be2e7a4af3a

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCN(NC(=O)Cc2ccccc2)CC1
Phenylacetamidopiperazine hydrochloride
CC(C)(C)OC(=O)N1CCN(NC(=O)Cc2ccccc2)CC1
1-BOC-4-phenylacetamidopiperazine
CCc1nc(N2CCN(C(=O)OC(C)(C)C)CC2)c2cc(CC)sc2n1
2-ethyl-4-chloro-6-ethylthienopyrimidine
CCc1nc(N2CCN(C(=O)OC(C)(C)C)CC2)c2cc(CC)sc2n1
tert-butyl 4-(2,6-diethylthiopheno[3,2-e]pyrimidin-4-yl)piperazinecarboxylate
→
CCc1nc(N2CCN(C(=O)Cc3ccccc3)CC2)c2cc(CC)sc2n1
1-[4-(2,6-diethylthiopheno[3,2-e]pyrimidin-4-yl)piperazinyl]-2-phenylethan-1-one
Ausbeute 27.0%

Edukte

CC(C)(C)OC(=O)N1CCN(NC(=O)Cc2ccccc2)CC1
Phenylacetamidopiperazine hydrochloride
CC(C)(C)OC(=O)N1CCN(NC(=O)Cc2ccccc2)CC1
1-BOC-4-phenylacetamidopiperazine
CCc1nc(N2CCN(C(=O)OC(C)(C)C)CC2)c2cc(CC)sc2n1
2-ethyl-4-chloro-6-ethylthienopyrimidine
CCc1nc(N2CCN(C(=O)OC(C)(C)C)CC2)c2cc(CC)sc2n1
tert-butyl 4-(2,6-diethylthiopheno[3,2-e]pyrimidin-4-yl)piperazinecarboxylate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Phenylacetamidopiperazine hydrochloride (Example 141) was reacted 2-ethyl-4-chloro-6-ethylthienopyrimidine (Example 156) according to Example 87. Yield=27%, ES-MS: (M+H)+ 395.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07115741B2uspto-grants-2006_10