Reaktion #1328782

Reaktionsgleichung

3-cyclohexyl-3-oxopropanenitrile

hydroxylamine

→

5-amino-3-cyclohexylisoxazole

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solid was filtered off
2. 2
   Waschenwashed with 1N NaOH
3. 3
   TrocknenH2O and dried over P2O5

Vorschrift

To a stirred solution of 3-cyclohexyl-3-oxopropanenitrile (1 g, 6.6 mmol, Step A) in EtOH (1 mL) at RT was added hydroxylamine (0.81 mL, 50% in H2O). The reaction was stirred 12 h at RT. The solid was filtered off, washed with 1N NaOH, then H2O and dried over P2O5 to give 5-amino-3-cyclohexylisoxazole.

Quelle