Reaktion #1328680

Reaktionsgleichung

4-tert-butyl-N-[1-(3-tert-butyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclohexanecarboxamide

phosphoric trichloride

→

2-tert-Butyl-7-(4-tert-butylcyclohexyl)-5-ethylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 3 hours
2. 2
   SonstigeThe resulting mixture is separated into the pure cis- and trans-isomers via silica gel chromatography with eluent cyclohexane/ethylacetate 10/1, 5/1

Vorschrift

In analogy to the procedure for Example 1, 377 mg (1.00 mmol) crude 4-tert-butyl-N-[1-(3-tert-butyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclohexanecarboxamide, 184 mg (1.20 mmol) phosphoric trichloride are stirred at reflux for 3 hours, proportionate amounts of the solvents are used. The resulting mixture is separated into the pure cis- and trans-isomers via silica gel chromatography with eluent cyclohexane/ethylacetate 10/1, 5/1.

Quelle