Reaktion #1328677

ord-7430f96f69964f2dae79215de9da8d9e

Reaktionsgleichung

CCC(N)c1nnc(C(C)(C)C)[nH]c1=O
6-(1-aminopropyl)-3-tert-butyl-1,2,4-triazin-5(4H)-one
CC(C)(C)C1CCC(C(=O)Cl)CC1
4-tert-butylcyclohexanecarbonyl chloride
→
CCC(NC(=O)C1CCC(C(C)(C)C)CC1)c1nnc(C(C)(C)C)[nH]c1=O
4-tert-Butyl-N-[1-(3-tert-butyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclohexanecarboxamide

Edukte

CCC(N)c1nnc(C(C)(C)C)[nH]c1=O
6-(1-aminopropyl)-3-tert-butyl-1,2,4-triazin-5(4H)-one
CC(C)(C)C1CCC(C(=O)Cl)CC1
4-tert-butylcyclohexanecarbonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe crude product is used in the next step without further purification

Vorschrift

In analogy to the procedure for Example 36A, 210 mg (1.00 mmol) 6-(1-aminopropyl)-3-tert-butyl-1,2,4-triazin-5(4H)-one, 200 mg (1.00 mmol) 4-tert-butylcyclohexanecarbonyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07115602B2uspto-grants-2006_10