Reaktion #1328417

Reaktionsgleichung

sodium hypochlorite

2-allyl-6-chlorobenzaldehyde oxime

sodium acetate

→

8-Chloro-3a,4-dihydro-3H-indeno[1,2-c]isoxazole

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe organic phase was separated off
2. 2
   Extraktionthe aqueous phase was extracted with methylene chloride
3. 3
   Waschenthe combined organic phases were washed with saturated ammonium chloride solution
4. 4
   SonstigeThe organic phase was dried
5. 5
   Sonstigethe solvent was removed

Vorschrift

At room temperature, 37.0 ml of a sodium hypochlorite solution (12.5% of active chlorine) were added dropwise to a solution of 8.4 g (42.9 mmol) of 2-allyl-6-chlorobenzaldehyde oxime in 100 ml of methylene chloride, and a spatula tip of sodium acetate was added. The mixture was stirred at room temperature for 2 hours, the organic phase was separated off, the aqueous phase was extracted with methylene chloride and the combined organic phases were washed with saturated ammonium chloride solution. The organic phase was dried and the solvent was removed. This gave 7.0 g (94%) of 8-chloro-3a,4-dihydro-3H-indeno-[1,2-c]isoxazole in the form of a viscous oil.

Quelle