Reaktion #1287293

Reaktionsgleichung

5H-Dibenz[b,g]oxocin-6(7H)-one

N-methylpiperazine

water

→

6-(4-methyl-1-piperazinyl)-5H-dibenz[b,g]oxocine

Lösungsmittel

methylbenzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeremoved via a Dean and Stark trap
2. 2
   SonstigeThe reaction mixture was then evaporated to dryness
3. 3
   workup.ADDITIONthe product re-treated
4. 4
   SonstigeThe final residue was triturated with methanol

Vorschrift

5H-Dibenz[b,g]oxocin-6(7H)-one (3 g) was dissolved in a mixture of methylbenzene (30 ml) and N-methylpiperazine (2.25 ml) and the solution was refluxed for sixteen hours, with water being removed via a Dean and Stark trap. The reaction mixture was then evaporated to dryness and the product re-treated, as described above, a further two times. The final residue was triturated with methanol to give 6-(4-methyl-1-piperazinyl)-5H-dibenz[b,g]oxocine. M.P. 127° C.

Quelle