Reaktion #1287053

Reaktionsgleichung

3-amino-1,2-propanediol

4,5-methylenedioxy-1,2-dinitrobenzene

triethylamine

ethanol

→

expected product

2-(β,γ-dihydroxypropyl)amino-4,5-methylenedioxy-1-nitrobenzene

Lösungsmittel

water

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux
2. 2
   Sonstigeprepared
3. 3
   TemperaturThe reaction mixture is heated for 3 hours
4. 4
   Temperaturunder reflux

Vorschrift

0.6 mol (56.3g) of 3-amino-1,2-propanediol is added dropwise to a mixture, brought to reflux, prepared by adding 0.3 mol (63.6 g) of 4,5-methylenedioxy-1,2-dinitrobenzene and 46 ml of triethylamine to 90 ml of 96° strength ethanol. The reaction mixture is heated for 3 hours under reflux. After dilution with 600 ml of icecold water and neutralization with acetic acid, the expected product is drained. After recrystallization from acetonitrile, it melts at 120°-121° C.

Quelle