Reaktion #1285218

ord-b58da569ef7a413ca3c57ca8e5249cc1

Reaktionsgleichung

O=C(O)C1(c2ccccc2)CCCC1
1-phenyl-1-cyclopentanecarboxylic acid
O=C(n1ccnc1)n1ccnc1
1,1'-carbonyldiimidazole
[Cl-].[Cl-].[Mg+2]
magnesium chloride
C[CH2][K].O=C(O)CC(=O)O
ethyl potassium malonate
CCN(CC)CC
triethylamine
CCOC(=O)CC(=O)C1(c2ccccc2)CCCC1
title compound
CCOC(=O)CC(=O)C1(c2ccccc2)CCCC1
β-oxo-1-phenylcyclopentanepropanoic acid ethyl ester

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from 1-phenyl-1-cyclopentanecarboxylic acid (50.0 g, 0.220 mol), 1,1'-carbonyldiimidazole (43.0 g, 0.265 mol), magnesium chloride (40.0 g, 0.418 mol), ethyl potassium malonate (60.0 g, 0.352 mol), and triethylamine (48.9 g, 0.484 mol) using the procedure described in Example 3, Step A.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05278326uspto-grants-1994_01