Reaktion #1285026

Reaktionsgleichung

Methyl (±)-[5-(aminophenylmethyl)-1H-benzimidazol-2-yl]carbamate

HCl

→

Methyl (±)-[5-[Amino (Phenyl)Methyl]-1H-Benzimidazol-2-yl]Carbamate Dihydrochloride Salt

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGAs stirring
2. 2
   Sonstigeprecipitated from the solution
3. 3
   TemperaturThe mixture was cooled in an ice bath
4. 4
   Filtrationthe title product as a precipitate was collected by filtration, m.p.>300° C

Vorschrift

Methyl (±)-[5-(aminophenylmethyl)-1H-benzimidazol-2-yl]carbamate (1 g) was suspended in water (5 mL). To this mixture was added aqueous HCl (12N) with stirring to adjust the pH to ph ~2. As stirring was continued the hydrochloride salt precipitated from the solution. The mixture was cooled in an ice bath and the title product as a precipitate was collected by filtration, m.p.>300° C. Yield: 1.05 g (ca. 85%).

Quelle