Reaktion #1284640

Reaktionsgleichung

2-phenyl-4-(1-hydroxyethyl)-5-methylimidazole

thionyl chloride

→

2-phenyl-4-(1-chloroethyl)-5-methylimidazole hydrochloride

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 5 hours
2. 2
   TemperaturAfter cooling
3. 3
   Sonstigethe mixture was evaporated
4. 4
   Sonstigethe residue triturated in acetone

Vorschrift

27 Grams (0.13 mol) of 2-phenyl-4-(1-hydroxyethyl)-5-methylimidazole were dissolved in 700 ml of chloroform with 44 ml (0.6 mol) of thionyl chloride and refluxed for 5 hours. After cooling, the mixture was evaporated, the residue triturated in acetone, thereby giving, in approximately stoichiometric yield, 2-phenyl-4-(1-chloroethyl)-5-methylimidazole hydrochloride, m.p. 190° C.

Quelle