Reaktion #1283901

Reaktionsgleichung

N-[1,3-dimethyl-2,4-dioxopyrimidine-6-yl]-N'-ethylethylenediamine

N-(1,3-dimethyl-2,4-dioxopyrimidine-6-yl)-N'-ethylethylenediamine

Compound 13

N-(1,3-dimethyl-2,4-dioxopyrimidine-6-yl)-N'-ethylethylenediamine

3-(3-methyl-4-oxo-4H-1-benzopyran-5-yl)oxypropyl bromide

Compound 2

3-(3-methyl-4-oxo-4H-1-benzopyran-5-yl)oxypropyl bromide

dimethyl sulfoxide

→

1,3-dimethyl-6-(2-[N-ethyl-N-[3-(3-methyl-4-oxo-4H-1-benzopyran-5-yl)oxypropyl]amino]ethylamino)-2,4(1H,3H)-pyrimidinedione

Lösungsmittel

triethylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resultant reaction solution
2. 2
   Temperaturwas cooled
3. 3
   Filtrationthe formed white crystals were collected by filtration
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried

Vorschrift

To 5 ml of dimethyl sulfoxide were added 0.52 g of the previously obtained N-[1,3-dimethyl-2,4-dioxopyrimidine-6-yl]-N'-ethylethylenediamine (Compound 13), 0.7 g of 3-(3-methyl-4-oxo-4H-1-benzopyran-5-yl)oxypropyl bromide (Compound 2) and 0.5 ml of triethylamine, and reaction was carried out at 100° C. for 6 hours. The resultant reaction solution was cooled, and the formed white crystals were collected by filtration, washed with water, and then dried, thereby obtaining 0.56 g of 1,3-dimethyl-6-(2-[N-ethyl-N-[3-(3-methyl-4-oxo-4H-1-benzopyran-5-yl)oxypropyl]amino]ethylamino)-2,4(1H,3H)-pyrimidinedione (the non-oxalate of Compound 14).

Quelle