Reaktion #1282976

Reaktionsgleichung

water

sulfuric acid

α-thiocyanoacetophenone

→

2-Hydroxy-4-phenylthiazole

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePrecipitated crystals
2. 2
   Filtrationwere collected by filtration
3. 3
   Waschenwashed with water, whereby the title compound
4. 4
   Sonstigewas obtained a colorless crystals

Vorschrift

Following the known process [Bull. Soc. Chem. France, 11, 2498 (1963)], 8.85 g (50 mmol) of α-thiocyanoacetophenone, 5 ml, of water and 1.3 ml of concentrated sulfuric acid were added to 40 ml of acetic acid and the resultant mixture was refluxed for 2 hours. The reaction mixture was then allowed to stand overnight at room temperature. Precipitated crystals were collected by filtration and then washed with water, whereby the title compound was obtained a colorless crystals.

Quelle