Reaktion #1281876

Reaktionsgleichung

potassium hydroxide

compound

8,10-Dichloro-1,2,3,4-tetrahydro-2-methylbenzo[b][1,6]naphthyridine

phenol

aniline

→

10-Anilino-8-chloro-1,2,3,4-tetrahydro-2-methylbenzo[b][1,6]naphthyridine

Lösungsmittel

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeis reacted
2. 2
   FiltrationThe insoluble product is filtered
3. 3
   Sonstigerecrystallized from acetonitrile giving the title compound (13.0 g, 72%), m.p. 137°-139° C.

Vorschrift

By the method described for Example 14, a mixture of the compound of Example 6 (15.0 g, 0.0562 mol), 10.69 (0.115 mol) of phenol and 10.3 mol (0.115 mol) of aniline is reacted. Thereafter, the reaction mixture is slurried with a mixture of 10% aqueous potassium hydroxide and diethyl ether. The insoluble product is filtered and recrystallized from acetonitrile giving the title compound (13.0 g, 72%), m.p. 137°-139° C.

Quelle