Reaktion #1281875

Reaktionsgleichung

compound

8,10-Dichloro-1,2,3,4-tetrahydro-2-methylbenzo[b][1,6]naphthyridine

phenol

→

title compound

8-Chloro-1,2,3,4-tetrahydro-2-methyl-10-phenoxybenzo[b][1,6]naphthyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeis reacted
2. 2
   Sonstigeto obtain the free base which
3. 3
   Sonstigeis recrystallized three times from hexane

Vorschrift

A mixture of the compound of Example 6 (5.0 g, 0.018 mol) and phenol (3.38 g, 0.036 mol) is reacted as described for Example 14 to obtain the free base which is recrystallized three times from hexane to afford the title compound as a crystalline solid, m.p. 182°-184° C.

Quelle