Reaktion #1279375

Reaktionsgleichung

5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid

8-methyl-8-azabicyclo[3.2.1]octan-3-amine

→

title compound

5-((3,5-dichloropyridin-4-yl)thio)-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-4-nitrothiophene-2-carboxamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePrepared

Vorschrift

Prepared according to the procedure described for example 70 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (150 mg, 0.43 mmol) and 8-methyl-8-azabicyclo[3.2.1]octan-3-amine (71.0 mg, 0.52 mmol). The title compound was obtained as a solid (40 mg, 20% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.97 (2H, m), 8.52 (1H, s), 8.44 (1H, s), 3.85 (1H, m), 3.79 (2H, m), 2.64 (3H, m), 2.25 (2H, m), 2.22 (4H, m), 2.16 (2H, m). MS m/z: 475.35, 477.33 [M+H]+.

Quelle