Reaktion #1278069

Reaktionsgleichung

1,3-dimethyl 5-aminobenzene-1,3-dicarboxylate

4,7-dichloroquinoline

→

expected compound

Ausbeute 78.2%

1,3-Dimethyl 5-[(7-chloroquinolin-4-yl)amino]benzene-1,3-dicarboxylate

Ausbeute 78.2%

Lösungsmittel

ethanol

—

petroleum ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe precipitate was removed by filtration
2. 2
   Waschenwashed successively with a saturated aqueous solution of NaHCO3, water, ethanol

Vorschrift

1,3-dimethyl 5-aminobenzene-1,3-dicarboxylate (2.09 g, 10 mmol) and 4,7-dichloroquinoline (1.98 g, 1 eq) were refluxed in 200 mL of ethanol for 3 h. The reaction mixture was then cooled to room temperature and the precipitate was removed by filtration and washed successively with a saturated aqueous solution of NaHCO3, water, ethanol and then petroleum ether to yield expected compound as a yellow powder (2.90 g, 78% yield). m/z (ESI) 371.0 [M+H]+.

Quelle