Reaktion #1275

Reaktionsgleichung

sodium hydroxide

sulfuric acid

Trans-1,2-indandiol

acetonitrile

acetonitrile

Water

→

cis-1-amino-2-indanol

Ausbeute 63.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was gradually warmed to 20° C. and aged to 3 hours
2. 2
   Temperaturthe mixture heated to reflux
3. 3
   SonstigeThe resulting solid was removed by filtration

Vorschrift

Trans-1,2-indandiol (1.5 g) was dissolved in acetonitrile (25 mL) cooled to 0° C., and concentrated sulfuric acid (1.1 mL) was added. The mixture was gradually warmed to 20° C. and aged to 3 hours. Water (2 mL) was added and the mixture heated to reflux. Concentrated aqueous sodium hydroxide was added to adjust the pH to 12. The resulting solid was removed by filtration to provide an aqueous acetonitrile solution of cis-1-amino-2-indanol (1.02 g, 63% yield).

Quelle