Reaktion #1273600

Reaktionsgleichung

3-Hydroxymethyl-5-methylpyridine

→

3-formyl-5-methylpyridine

Ausbeute 98.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered through Celite
2. 2
   Sonstigethe solvent was evaporated off under reduced pressure
3. 3
   SonstigeThe residue was purified by silica gel column chromatography (chloroform/methanol=19/1)

Vorschrift

3-Hydroxymethyl-5-methylpyridine (972 mg, 7.89 mmol) was dissolved in dichloromethane (30 mL). To this, manganese dioxide (7.5 g) was added and the mixture was stirred at room temperature for 1 hour. The reaction mixture was filtered through Celite and the solvent was evaporated off under reduced pressure. The residue was purified by silica gel column chromatography (chloroform/methanol=19/1) to give 3-formyl-5-methylpyridine (936 mg, yield: 98%).

Quelle