Reaktion #1273550

Reaktionsgleichung

4-methylthiazole-5-carbaldehyde

potassium carbonate

(trifluoromethyl)trimethylsilane

→

2,2,2-trifluoro-1-(4-methylthiazol-5-yl)ethanol

Ausbeute 84.5%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereacted at room temperature for 2.2 hours
2. 2
   SonstigeThen, purification by preparative thin-layer chromatography (chloroform/methanol=15/1)

Vorschrift

According to Reference Example 8-2, by use of 4-methylthiazole-5-carbaldehyde (300 mg, 2.36 mmol) dissolved in N,N-dimethylformamide (4 mL), potassium carbonate (65 mg, 0.47 mmol) and (trifluoromethyl)trimethylsilane (0.419 mL, 2.83 mmol), the mixture was stirred and reacted at room temperature for 2.2 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give 2,2,2-trifluoro-1-(4-methylthiazol-5-yl)ethanol (Compound DT) (393 mg, yield: 84%).

Quelle