Reaktion #1270677

Reaktionsgleichung

Cyclobutanol

sodium hydride

2,6-dibromo-pyridine

→

title compound

2-Bromo-6-cyclobutoxy-pyridine

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction was heated to 110° C. for 16 hours
2. 2
   Temperaturthen cooled to room temperature
3. 3
   Filtrationfiltered through Celite
4. 4
   Sonstigepurified on silica gel (0-5% EtOAc in hexanes)

Vorschrift

Cyclobutanol (0.470 mL, 6 mmol) was dissolved in toluene (2 mL) and sodium hydride (60% in mineral oil, 0.240 g, 6 mmol) was added. The reaction was stirred at room temperature for 10 minutes then 2,6-dibromo-pyridine (0.710 g, 3 mmol) was added. The reaction was heated to 110° C. for 16 hours then cooled to room temperature, filtered through Celite, and purified on silica gel (0-5% EtOAc in hexanes) to give the title compound.

Quelle