Reaktion #1270676

ord-dc185cd988f44ad59ad0acda7d79e51a

Reaktionsgleichung

CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4N)cc3)cc2)CC1
1-[4′-(4-amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester
Brc1cccc(OC2CCCCC2)n1
2-bromo-6-cyclohexyloxy-pyridine
→
CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4Nc4cccc(OC5CCCCC5)n4)cc3)cc2)CC1
1-{4′-[4-(6-Cyclohexyloxy-pyridin-2-ylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

Edukte

CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4N)cc3)cc2)CC1
1-[4′-(4-amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester
Brc1cccc(OC2CCCCC2)n1
2-bromo-6-cyclohexyloxy-pyridine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared according to the procedure described in Example 134, Step 3, using 1-[4′-(4-amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester and 2-bromo-6-cyclohexyloxy-pyridine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08664220B2uspto-grants-2014_03