Reaktion #1269881

Reaktionsgleichung

4-chloronicotinic acid

benzylamine

→

4-(benzylamino)nicotinic acid

Lösungsmittel

MeCN

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solution obtained
2. 2
   Sonstigewas partitioned between water and EtOAc
3. 3
   SonstigeThe precipitate formed
4. 4
   Filtrationwas filtered off
5. 5
   Waschenwashed with water, EtOAc
6. 6
   Sonstigedried in vacuo

Vorschrift

A mixture of 4-chloronicotinic acid (300 mg, 1.90 mmol) and benzylamine (408 mg, 3.81 mmol) in MeCN (3 mL) was stirred and heated in the microwave (80° C., 200 W) for 1 h. The solution obtained was partitioned between water and EtOAc. The precipitate formed was filtered off, washed with water, EtOAc and dried in vacuo. 4-(benzylamino)nicotinic acid was obtained as a colourless solid (147 mg, 34%). ESI-MS [M+H]+=229.1.

Quelle