Reaktion #1269870

ord-e167651553d349bcbe2ded3bd9855947

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCC2(CCN(C(=O)c3ccccc3)C2)C1
tert-butyl 7-benzoyl-2,7-diazaspiro[4.4]nonane-2-carboxylate
→
O=C(c1ccccc1)N1CCC2(CCNC2)C1
phenyl(2,7-diazaspiro[4.4]nonan-2-yl)methanone

Edukte

CC(C)(C)OC(=O)N1CCC2(CCN(C(=O)c3ccccc3)C2)C1
tert-butyl 7-benzoyl-2,7-diazaspiro[4.4]nonane-2-carboxylate

Reagenzien

Keine

Lösungsmittel

O=C(O)C(F)(F)F
TFA
ClCCl
CH2Cl2

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeAfter removal of solvents
  2. 2
    Sonstigethe residue, phenyl(2,7-diazaspiro[4.4]nonan-2-yl)methanone, was used in the further reactions without purification

Vorschrift

tert-butyl 7-benzoyl-2,7-diazaspiro[4.4]nonane-2-carboxylate (100 mg) was dissolved in 10% TFA solution in CH2Cl2 (10 mL). The reaction was stirred at room temperature for 24 hours. After removal of solvents, the residue, phenyl(2,7-diazaspiro[4.4]nonan-2-yl)methanone, was used in the further reactions without purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08664213B2uspto-grants-2014_03